The SERTOMA Butterfly House is located in SERTOMA Park in the southern part of Sioux Falls and is easily accessible from both I-90 and I-29. Other nearby attractions (within 1 mile) include the Outdoor Campus, the Empire and Empire East shopping malls as wells as many restaurants and motels.
Other Sioux Falls attractions such as the Great Plains Zoo and Delbridge Museum, the Battleship South Dakota Memorial, the Siouxland Heritage Museum, the Pettigrew Museum and Falls Park are located within 8 miles of the Butterfly House.